Harris Perlman, PhD is Chief of Rheumatology and the Mabel Greene Myers Professor of Medicine and was the co-senior author of a USA-based study that used genetic profiling of joint tissue to see which drugs would work for which patients. Over the past 22 years, his area of interest has centered on rheumatic disease. His laboratory focuses on using functional genomics and clinomics to development precision medicine approach for the treatment of rheumatoid arthritis (RA) and systemic sclerosis (SSc). Dr. Perlman has created a central digital biorepository for peripheral blood, serum and tissues (synovial biopsy) from RA and SSc (esophageal, skin, BAL) patients. Single cell populations of immune cells are analyzed from these biopsies via spatial transcriptomics as well as CITE, RNA and ATAC seq. Thus, by using the cutting-edge technologies, data has the potential to be paradigm shifting and transformative to understand the function of individual populations of monocytes and macrophages in relationship to developing a precision medicine approach for their patients.